(1) Imaging techniques used by the team can demonstrate extremely subtle changes in the structures of the brain as the disease progresses and detect any change in response to treatment.(2) There is another, parsimonious explanation that escapes many would be subtle minds.(3) Although there are subtle changes on Parade, it's not radically dissimilar to what fans have come to expect.(4) But the serpent was as subtle and cunning as ever, more than any other beast who dwelt within the garden which the Gods had made.(5) They would prefer more subtle methods of signaling unhappiness with a stock.(6) Lynn's method is at once subtle and mechanical.(7) No study can adequately predict the long-term and subtle effects of a vaccine prior to its introduction to a group as large as most of the population of our planet.(8) Some of us have a finely tuned nose, able to detect subtle differences and describe fragrance with colourful adjectives such as musky, syrupy and spicy.(9) Some of the solutions to your problems are very subtle and clever.(10) However, when both languages are in the same book, subtle differences make it difficult for some readers, usually those reading in Spanish.(11) This elusive goal requires a deep understanding of the components of speech and of the subtle effects of a person's volume, pitch, timing and emphasis.(12) The rum opens up the subtle and elaborate world of flavours within each chocolate.(13) Various sweet dishes, of which ice cream is the most obvious example, can be given a subtle tea flavour, but some is also used in some parts of the world for savoury dishes.(14) The way he used elements of other film scores for certain subtle effects.(15) Limes have a stimulating, wake-me-up freshness that sets off the less obvious flavours of more subtle fruits and vegetables.(16) But mostly change is subtle , almost delicate, and it is viewed most clearly not from the stand or drawing room but with a squint-eyed look from across the net.