(1) Alcohol has two anticoagulant effects which make blood less likely to clot in the wrong place.(2) Aspirin has a direct irritant effect on stomach lining and can cause stomach bleeding, and it increases the risk of bleeding due to enhancement of the anticoagulant effect of warfarin.(3) These include a change in the balance between procoagulant and anticoagulant factors in the blood.(4) They have a more predictable anticoagulant effect and cause less thrombocytopenia.(5) These characteristics result in a more prolonged and predictable anticoagulant effect and less bleeding.(6) As there is an exponential increase in bleeding risk with a linear increase in anticoagulant effect, there will be a substantial increase in bleeding risk with overanticoagulation.(7) Large amounts of garlic can increase the anticoagulant effects of pharmaceutical blood thinners (warfarin, high dose aspirin).(8) Coagulation studies would be indicated if the patient is receiving anticoagulant therapy, has a family or personal history that suggests a bleeding disorder or has evidence of liver disease.(9) Chinese patients are reportedly more sensitive than Caucasians to the anticoagulant effect of warfarin.(10) This anticoagulant effect might indeed explain why your lab results have been changing.(11) Furthermore, almost any drug can interact with oral anticoagulants, and many (such as steroids and antibiotics) often increase the anticoagulant effect.(12) This mutant exhibits lowered activation rates and anticoagulant activity.(13) Difenacoum, detected in her blood samples, can be absorbed through skin, with prolonged anticoagulant effects.(14) Herbs with anticoagulant effects include herbs that have blood-activating and blood-stasis-removing functions.(15) The unit's pump and the blood set are specially designed to cooperate during the collection process to assure that the collected product has a precise blood to anticoagulant ratio.(16) The identification of new genetic variants that may either directly or indirectly affect coagulation or the anticoagulant pathway, may greatly advance the understanding and clinical management of thrombophilia.
